phosphopantothenoylcysteine decarboxylase; PPC-DC; coaC (PPCDC, COAC, MDS018, UNQ9365/PRO34154)

Function

• biosynthesis of coenzyme A, 3rd step
• catalyzes decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine
• homotrimer

 N-((R)-4'-phosphopantothenoyl)-L-cysteine

                  PPCDC
                  <-->

       pantotheine 4'-phosphate + CO2

Cofactor: binds 1 FMN per subunit

Structure

• belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily

Alternative splicing

named isoforms=2

More general terms

• carboxy-lyase or decarboxylase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=60490
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:60490
• OMIM: https://mirror.omim.org/entry/609854
• UniProt: http://www.uniprot.org/uniprot/Q96CD2.html