sulfotransferase 1A2; aryl sulfotransferase 2; phenol sulfotransferase 2; phenol-sulfating phenol sulfotransferase 2; P-PST 2; ST1A2 (SULT1A2, STP2)

Function

• catalyzes sulfate conjugation of catecholamines, phenolic drugs & neurotransmitters
• also responsible for sulfation & activation of minoxidil

3'-phosphoadenylyl sulfate + a phenol
             <-->
adenosine 3',5'-bisphosphate + an aryl sulfate

Structure

• homodimer (putative)
• belongs to the sulfotransferase 1 family

Compartment

cytoplasm

Pathology

• mediates metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products thus may play role in the initiation of carcinogenesis

More general terms

• sulfotransferase

Database

• OMIM: https://mirror.omim.org/entry/601292
• UniProt: http://www.uniprot.org/uniprot/P50226.html