tRNA guanine-N1-methyltransferase (M1G-methyltransferase, tRNA [GM37] methyltransferase, tRNA methyltransferase 5, TRMT5, KIAA1393)

Function

• specifically methylates guanosine-37 in various tRNAs
• not dependent on the nature of the nucleoside 5' of the target nucleoside

S-adenosyl-L-methionine + tRNA
             <-->
S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine

Structure

• monomer
• belongs to the RNA methyltransferase trmD family

Compartment

cytoplasm

More general terms

• methyltransferase

Database

• UniProt: http://www.uniprot.org/uniprot/Q32P41.html