glutathione S-transferase theta-1 (GST class-theta-1, glutathione transferase T1-1, GSTT1)

Function

• conjugation of reduced glutathione to a wide number of exogenous & endogenous hydrophobic electrophiles
• acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride & 4-nitrophenethyl bromide
• displays glutathione peroxidase activity with cumene hydroperoxide

RX + glutathione <--> HX + R-S-glutathione

Structure

• homodimer
• belongs to the GST superfamily. Theta family

Compartment

cytoplasm

Expression

• found in erythrocyte
• expressed at low levels in liver
• in lung, expressed at low levels in Clara cells & ciliated cells at the alveolar/bronchiolar junction, absent from epithelial cells of larger bronchioles

Polymorphism

• the GSTT1 gene is absent from 38% of the population
• the presence or absence of the GSTT1 gene is coincident with the conjugator (GSST1+) & non-conjugator (GSTT1-) phenotypes respectively
• the GSTT1+ phenotype can catalyze the glutathione conjugation of dichloromethane

Laboratory

• glutathione S-transferase T1 Ab in serum

More general terms

• glutathione transferase

Database

• UniProt: http://www.uniprot.org/uniprot/P30711.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2952
• OMIM: https://mirror.omim.org/entry/600436