lysocardiolipin acyltransferase; acyl-CoA:lysocardiolipin acyltransferase 1; 1-AGP acyltransferase 8; 1-AGPAT 8 (LYCAT, LCLAT1, AGPAT8, ALCAT1, UNQ1849/PRO3579)

Function

• acyl-CoA:lysocardiolipin acyltransferase
• recognizes both monolysocardiolipin & dilysocardiolipin as substrates with a preference for linoleoyl-CoA & oleoyl-CoA as acyl donors
• acts as a remodeling enzyme for cardiolipin (putative)
• converts lysophosphatidic acid into phosphatidic acid with relatively low activity
• de novo phospholipid biosynthesis, 2nd step

acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
              <-->
CoA + 1,2-diacyl-sn-glycerol 3-phosphate

Structure

• HXXXXD motif is essential for acyltransferase activity & may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (putative)
• belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

Compartment

endoplasmic reticulum membrane

Alternative splicing

named isoforms=2

Expression

• expressed at higher level in heart, kidney than in brain, spleen, liver, small intestine & placenta

Notes

acyl-CoA:lysocardiolipin acyltransferase activity

More general terms

• acyltransferase
• transmembrane 4 protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6UWP7.html