diacylglycerol O-acyltransferase 2

Function

• acyltransferase using diacylglycerol & fatty acyl CoA as substrates
• catalyzes terminal & only committed step in triacylglycerol synthesis
• synthesis & storage of intracellular triglycerides
• cytosolic lipid accumulation
• inhibited by niacin

acyl-CoA + 1,2-diacylglycerol <--> CoA + triacylglycerol

Compartment

endoplasmic reticulum membrane

Alternative splicing

named isoforms=2

Expression

• expressed in liver & white adipose tissue > mammaray gland, testis, peripheral blood leukocytes.

Pathology

• expressed in sebaceous glands of normal skin but decreased exrpression in psoriatic skin

More general terms

• acyltransferase
• transmembrane 2 protein

Database

• OMIM: https://mirror.omim.org/entry/606983
• UniProt: http://www.uniprot.org/uniprot/Q96PD7.html