acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (LPGAT1, FAM34A, KIAA0205)

Function

• lysophoshatidylglycerol-specific acyltransferase
  • preference for long chain saturated fatty acyl-CoAs
  • prefers oleoyl-LPG > palmitoyl-LPG, lauroyl-CoA

Structure

• the HXXXXD motif is essential for acyltransferase activity & may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (putative)
• belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

Compartment

endoplasmic reticulum

Expression

• highly expressed in liver, placenta > peripheral blood, lung, kidney, brain > colon

More general terms

• acyltransferase
• transmembrane 2 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9926
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9926
• OMIM: https://mirror.omim.org/entry/610473
• UniProt: http://www.uniprot.org/uniprot/Q92604.html