protein-cysteine N-palmitoyltransferase HHAT; Hedgehog acyltransferase; melanoma antigen recognized by T-cells 2; MART-2; skinny hedgehog protein 1 (HHAT, MART2, SKI1)

Function

• catalyzes N-terminal palmitoylation of SHH
• may bind GTP

Structure

• belongs to the membrane-bound acyltransferase family HHAT subfamily

Compartment

endoplasmic reticulum, membrane

Alternative splicing

named isoforms=4

Expression

• ubiquitously expressed in normal tissues & cancer cell lines

More general terms

• acyltransferase
• transmembrane 10 protein

Component of

• BRE1A/BRE1B/UBE2E1 (RNF20/40) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55733
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55733
• OMIM: https://mirror.omim.org/entry/605743
• UniProt: http://www.uniprot.org/uniprot/Q5VTY9.html