peptide N-myristoyltransferase (myristoyl-CoA:protein N-myristoyltransferase, NMT, NMT1, glycylpeptide N-tetradecanoyltransferase)
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Function
- N-myristoyl transferase is active cotranslationally on polyribosomes
- myristoylation of N-terminal glycine residues is generally constitutive resulting in a stably modified protein that associates with cellular membranes[2]
Structure
belongs to the NMT family
Compartment
Alternative splicing
named isoforms=2
Expression
expressed in heart, gut, kidney, liver, placenta
More general terms
Additional terms
- glycylpeptide N-tetradecanoyltransferase 2; Myristoyl-CoA:protein N-myristoyltransferase 2; NMT 2; peptide N-myristoyltransferase 2; type II N-myristoyltransferase (NMT2)
- myristoylation
- myristoylation site
References
- ↑ Sefton & Buss J Cell Biol 104:1449 1987
- ↑ 2.0 2.1 Casey PJ Protein lipidation in cell signaling. Science 268:221 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7716512