alpha-1,2-mannosyltransferase ALG9 (asparagine-linked glycosylation protein 9 homolog, disrupted in bipolar disorder protein 1, ALG9, DIBD1)

Function

• glycosylation
• catalyzes transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides

Structure

• belongs to the glycosyltransferase 22 family

Compartment

endoplasmic reticulum

Alternative splicing

named isoforms=4

Expression

• ubiquitously expressed
• highest levels in heart, liver & pancreas

Pathology

• chromosomal translocation t(9;11)(p24;q23) involving ALG9 is found in afamily with bipolar affective disorder
• defects in ALG9 are the cause of congenital disorder of glycosylation type 2

More general terms

• glycosyltransferase
• transmembrane 8e protein

Database

• OMIM: https://mirror.omim.org/entry/606941
• OMIM: https://mirror.omim.org/entry/608776
• UniProt: http://www.uniprot.org/uniprot/Q9H6U8.html