dol-P-man:man(5)GlcNAc(2)-PP-dol alpha-1,3-mannosyltransferase; asparagine-linked glycosylation protein 3 homolog; dol-P-man-dependent alpha(1-3)-mannosyltransferase; dolichyl-P-man:man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase; dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase; not56-like protein (ALG3, NOT, NOT56L)

Function

• glycosylation
  • adds the first Dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol

Compartment

endoplasmic reticulum

Pathology

• defects in ALG3 associated with congenital disorder of glycosylation type 1D

Notes

ALG3 also maps to presenilin 2

More general terms

• glycosyltransferase
• transmembrane 11 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10195
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10195
• OMIM: https://mirror.omim.org/entry/601110
• OMIM: https://mirror.omim.org/entry/608750
• UniProt: http://www.uniprot.org/uniprot/Q92685.html