peroxisomal coenzyme A diphosphatase NUDT7; nucleoside diphosphate-linked moiety X motif 7; nudix motif 7 (NUDT7)

Function

• mediates the cleavage of CoA, CoA esters & oxidized CoA
• elimination of oxidized CoA from peroxisomes
• regulate CoA & acyl-CoA levels in peroxisome
• products: 3',5'-ADP & corresponding 4'-phosphopantetheine derivative
• inhibited by fluoride

    NUDT7
CoA  -----> 3',5'-ADP + 4'-phosphopantheine

Cofactor: Mn+2 or Mg+2

Compartment

peroxisome

Expression

• expressed in liver, kidney, pancreas, pituitary, small intestine, spleen, heart, placenta
• weakly expressed in brain

More general terms

• phosphodiesterase
• nucleoside diphosphate-linked moiety X motif

Database

• UniProt: http://www.uniprot.org/uniprot/P0C024.html