ADP-sugar pyrophosphatase; nucleoside diphosphate-linked moiety X motif 5; Nudix motif 5; YSA1H (NUDT5, HSPC115)

Function

• hydrolyzes ADP sugar pyrophosphatases; similar activity with
  • ADP-ribose
  • ADP-mannose
  • ADP-glucose
• other nucleotide sugars are hydrolyzed with low activity

ADP-ribose + H2O = AMP + D-ribose-5-phosphate

ADP-sugar + H2O = AMP + alpha-D-aldose-5-phosphate

Cofactor: binds 3 Mg+2 per subunit

Structure

• homodimer
• belongs to the Nudix hydrolase family
• contains 1 nudix hydrolase domain

Expression

• widely expressed
• most abundant in liver

More general terms

• pyrophosphatase (diphosphohydrolase)
• nucleoside diphosphate-linked moiety X motif
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11164
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11164
• OMIM: https://mirror.omim.org/entry/609230
• UniProt: http://www.uniprot.org/uniprot/Q9UKK9.html