acidic mammalian chitinase (AMCase, TSA1902, CHIA)

Function

• degrades chitin & chitotriose
• role in defense against nematodes & other pathogens
• random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin & chitodextrins

Structure

• belongs to the glycosyl hydrolase 18 family, Chitinase class 2 subfamily
• contains 1 chitin-binding type-2 domain

Compartment

secreted; isoform 2 & 3: cytoplasm

Alternative splicing

named isoforms=3

Expression

• highly expressed in stomach
• detected at lower levels in lung

More general terms

• glycosidase (glycoside hydrolase)

Database

• OMIM: https://mirror.omim.org/entry/606080
• UniProt: http://www.uniprot.org/uniprot/Q9BZP6.html