epoxide hydrolase 1 (microsomal epoxide hydrolase, EPHX1, EPHX, EPOX)

Function

• biotransformation enzyme that catalyzes hydrolysis of arene & aliphatic epoxides to less reactive & more water soluble dihydrodiols by the trans addition of water

cis-stilbene oxide + H2O
             <-->
(+)-(1R,2R)-1,2-diphenylethane-1,2-diol

Structure

belongs to the peptidase S33 family

Compartment

microsome membrane

Expression

found in liver

Pathology

• genetic variation in EPHX1 may be associated with susceptibility to preeclampsia
• defects in EPHX1 are a cause of familial hypercholanemia

More general terms

• epoxide hydrolase or epoxide hydratase

Database

• OMIM: https://mirror.omim.org/entry/132810
• OMIM: https://mirror.omim.org/entry/607748
• UniProt: http://www.uniprot.org/uniprot/P07099.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2052