alcohol dehydrogenase 1B (ADH-beta, alcohol dehydrogenase subunit beta, ADH1B, ADH2)

Function

-..........-

an alcohol + NAD+ <--> an aldehyde or ketone + NADH

Cofactor: binds 2 Zn+2 per subunit

Structure

• belongs to the Zn+2-containing alcohol dehydrogenase family

Compartment

cytoplasm

Expression

• active in lung early in fetal life & throughout adult life; becomes active in liver after 1st trimester & is responsible for most of liver activity in adulthood

Polymorphism

• 3 alleles are known:
  • ADH1B*1 (ADH2*1) corresponding to variant beta-1
  • ADH1B*2 (ADH2*2) corresponding to variant beta-2
    • ADH1B*2 allele frequency in orientals is ~ 75%, & < 5% in most Caucasian populations
  • ADH1B*3 (ADH2*3) corresponding to variant beta-3

More general terms

• protein subunit

Component of

• alcohol dehydrogenase (aldehyde reductase)

Database

• UniProt: http://www.uniprot.org/uniprot/P00325.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:125
• OMIM: https://mirror.omim.org/entry/103720
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=125