proline dehydrogenase 2 (kidney & liver proline oxidase 1, HsPOX1, PRODH2)

Function

• converts proline to delta-1-pyrroline-5-carboxylate (probable)
• amino-acid degradation, L-proline degradation into L- glutamate; L-glutamate from L-proline: step 1/2

L-proline + acceptor + H2O
            <-->
(S)-1- pyrroline-5-carboxylate + reduced acceptor

Cofactor: FAD (putative)

Structure

belongs to the proline oxidase family

More general terms

• dehydrogenase

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UF12.html