UDP-glucuronosyltransferase 2B15; UDPGT 2B15; HLUG4; UDP-glucuronosyltransferase 2B8; UDPGT 2B8; UDPGTh-3 (UGT2B15, UGT2B8)

Function

• UDPGTs are of major importance in the conjugation & subsequent elimination of potentially toxic xenobiotics & endogenous compounds
• displays activity toward several classes of xenobioticss, including:
  • simple phenolic compounds
  • 7-hydroxylated coumarins
  • flavonoids
  • anthraquinones
  • certain drugs & their hydroxylated metabolites
• catalyzes glucuronidation of endogenous estrogens & androgens

UDP-glucuronate + acceptor
              <-->
UDP + acceptor beta-D-glucuronoside

Structure

belongs to the UDP-glycosyltransferase family

Compartment

microsome

Expression

• expressed in many tissues. present in liver, prostate & testis

Notes

• previously referred to as UGT2B8
• UGT2B8 has now been reused for a rat enzyme

More general terms

• UDP-glucuronosyltransferase-2B (UDPGT-2B)

Additional terms

• UGT2B15 gene mutation
• UGT2B15 genotyping

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7366
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7366
• OMIM: https://mirror.omim.org/entry/600069
• UniProt: http://www.uniprot.org/uniprot/P54855.html