UDP-glucuronosyltransferase-2B4 (steroid metabolizing, HLUG25, UDPGTh-1, UGT2B4, UGT2B11UGT2B4)

Function

• UDPGTs are of major importance in the conjugation & subsequent elimination of potentially toxic xenobiotics & endogenous compounds
• active on polyhydroxylated estrogens (including estriol, 4-hydroxyestrone & 2-hydroxyestriol
• active on xenobiotics, including 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl & menthol
• capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid

UDP-glucuronate + acceptor
              <-->
UDP + acceptor beta-D-glucuronoside

Structure

belongs to the UDP-glycosyltransferase family

Compartment

microsome Previously referred to as UDP-glucuronosyltransferase-2B11

More general terms

• UDP-glucuronosyltransferase-2B (UDPGT-2B)

Database

• UniProt: http://www.uniprot.org/uniprot/P06133.html
• OMIM: https://mirror.omim.org/entry/600067
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7363