long-chain-fatty-acid-CoA ligase 3; long-chain acyl-CoA synthetase 3; LACS 3 (ACSL3, ACS3, FACL3, LACS3)

Function

• acyl-CoA synthetases activate long-chain fatty acids for both synthesis of cellular lipids, & degradation via beta-oxidation
• ACSL3 mediates hepatic lipogenesis
• preferentially uses myristate, laurate, arachidonate & eicosapentaenoate as substrates (putative)
• has mainly an anabolic role in energy metabolism
• required for incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins)

ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA

Cofactor: Mg+2 (putative)

Structure

• belongs to the ATP-dependent AMP-binding enzyme family

Compartment

• mitochondrial outer membrane
• peroxisome membrane
• microsome membrane
• endoplasmic reticulum membrane
• single-pass type 3 membrane protein (putative)

More general terms

• fatty-acid CoA ligase
• mitochondrial protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2181
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2181
• OMIM: https://mirror.omim.org/entry/602371
• UniProt: http://www.uniprot.org/uniprot/O95573.html