dolichyl pyrophosphate man9GlcNAc2 alpha-1,3-glucosyltransferase; asparagine-linked glycosylation protein 6 homolog; dol-P-Glc:man(9)GlcNAc(2)-PP-dol alpha-1,3-glucosyltransferase; dolichyl-P-Glc:man9GlcNAc2-PP-dolichyl glucosyltransferase (ALG6)

Function

• adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation
• transfers glucose from dolichyl phosphate glucose (dol-P-Glc) onto the lipid-linked oligosaccharide man(9)GlcNAc(2)-PP-dol
• protein modification; protein glycosylation

Structure

belongs to the ALG6/ALG8 glucosyltransferase family

Compartment

• endoplasmic reticulum membrane
• multi-pass membrane protein (putative)

Pathology

• defects in ALG6 are the cause of congenital disorder of glycosylation type 1C

More general terms

• glucosyl transferase
• transmembrane 11 protein

Additional terms

• dolichol pyrophosphate

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29929
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:29929
• OMIM: https://mirror.omim.org/entry/603147
• OMIM: https://mirror.omim.org/entry/604566
• UniProt: http://www.uniprot.org/uniprot/Q9Y672.html