phosphatidate cytidylyltransferase 2; CDP-DAG synthase 2; CDP-DG synthase 2; CDP-diacylglycerol synthase 2; CDS 2; CDP-diglyceride pyrophosphorylase 2; CDP-diglyceride synthase 2; CTP:phosphatidate cytidylyltransferase 2 (CDS2)

Function

• phospholipid biosynthesis
• provides CDP-diacylglycerol, precursor for phosphatidylinositol, phosphatidylglycerol, cardiolipin

Structure

belongs to the CDS family

Compartment

mitochondrial inner membrane, matrix side

Alternative splicing

named isoforms=4

Expression

• widely expressed
• expressed in heart, brain, retina > placenta, lung, liver, skeletal muscle, kidney, pancreas
• earliest expression E12.5 in developing CNS

More general terms

• nucleotidyltransferase
• transmembrane 6 protein
• mitochondrial protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8760
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8760
• OMIM: https://mirror.omim.org/entry/603549
• UniProt: http://www.uniprot.org/uniprot/O95674.html