mannose-P-dolichol utilization defect 1 protein; suppressor of lec15 & lec35 glycosylation mutation homolog; SL15 (MPDU1)

Function

• required for normal utilization of mannose-dolicholphosphate (dol-P-man) in the synthesis of N-linked oligosaccharides & O-linked oligosaccharides & GPI anchors (putative)

Structure

• belongs to the MPDU1 (TC 2.A.43.3) family
• contains 2 PQ-loop domains

Compartment

membrane (potential)

Pathology

• defects in MPDU1 are the cause of congenital disorder of glycosylation type 1F

More general terms

• transmembrane 5 protein

Additional terms

• dolichol phosphate mannose

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9526
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9526
• OMIM: https://mirror.omim.org/entry/604041
• OMIM: https://mirror.omim.org/entry/609180
• UniProt: http://www.uniprot.org/uniprot/O75352.html