1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; 1-acylglycerol-3-phosphate O-acyltransferase 3; 1-AGP acyltransferase 3; 1-AGPAT 3; lysophosphatidic acid acyltransferase gamma; LPAAT-gamma (AGPAT3)
Jump to navigation
Jump to search
Function
- converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (putative)
- phospholipid metabolism; CDP-diacylglycerol biosynthesis
- CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate =
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
Structure
- the HXXXXD motif is essential for acyltransferase activity & may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (putative)
- belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
Compartment
- endoplasmic reticulum membrane
Alternative splicing
named isoforms=3