translocation protein SEC63 homolog (SEC63, SEC63L)

Function

• required for integral membrane & secreted preprotein translocation across endoplasmic reticulum membrane
• part of the multicomponent translocon that contains the trimeric SEC61 complex

Structure

• contains 1 J domain

Compartment

endoplasmic reticulum membrane

Expression

• widely expressed, with high levels in liver

Pathology

• defects in SEC63 are a cause of autosomal dominant polycystic liver disease

More general terms

• transmembrane 3 protein

Component of

• Sec61 translocon complex

Database

• OMIM: https://mirror.omim.org/entry/174050
• OMIM: https://mirror.omim.org/entry/608648
• UniProt: http://www.uniprot.org/uniprot/Q9UGP8.html