1-acyl-sn-glycerol-3-phosphate acyltransferase beta; 1-acylglycerol-3-phosphate O-acyltransferase 2; 1-AGP acyltransferase 2; 1-AGPAT 2; lysophosphatidic acid acyltransferase beta; LPAAT-beta (AGPAT2)
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Function
- converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone
- phospholipid metabolism; CDP-diacylglycerol biosynthesis
CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate =
CoA + 1,2-diacyl-sn-glycerol 3-phosphate
Structure
- the HXXXXD motif is essential for acyltransferase activity & may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (putative)
- belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
Compartment
membrane (putative)
Alternative splicing
named isoforms=2
Expression
expressed predominantly in heart & liver
Pathology
- defects in AGPAT2 are the cause of Berardinelli-Seip congenital lipodystrophy type 1