methyl-CpG-binding domain protein 6; methyl-CpG-binding protein MBD6 (MBD6, KIAA1887)

Function

• binds to heterochromatin
• does not interact with either methylated DNA or unmethylated DNA (in vitro)

Structure

• the MBD domain is necessary for chromocentric localization
• contains 1 MBD (methyl-CpG-binding) domain

Compartment

• nucleus, chromosome
• associated with pericentric heterochromatin in ~ 25% of cells

More general terms

• methyl-CpG binding domain protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=114785
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:114785
• UniProt: http://www.uniprot.org/uniprot/Q96DN6.html