RNA polymerase 1 L (RNA polymerase 1 135 kD subunit, RPA135, RNA polymerase 1 subunit 2, POLR1B)

Function

• component of the RNA polymerase 1 complex
• second largest core component of RNA polymerase 1 which synthesizes ribosomal RNA precursors
• roposed to contribute to the polymerase catalytic activity & forms the polymerase active center together with the largest subunit (POLR1A)
• POLR1B is part of the core element with the central large cleft & probably a clamp element that moves to open & close the cleft (putative)

nucleoside triphosphate + RNA(n) <--> diphosphate + RNA(n+1)

Structure

belongs to the RNA polymerase beta chain family

Compartment

nucleus, nucleolus

Alternative splicing

named isoforms=2

More general terms

• RNA polymerase L

Component of

• RNA polymerase 1

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8417
• OMIM: https://mirror.omim.org/entry/602000
• UniProt: http://www.uniprot.org/uniprot/Q9H9Y6.html