RNA polymerase-3 L' (largest subunit); DNA-directed RNA polymerase 3 subunit RPC1; RNA polymerase 3 subunit C1; DNA-directed RNA polymerase 3 subunit A; DNA-directed RNA polymerase 3 largest subunit (RPC155, C160, POLR3A)

Function

• largest & catalytic core component of RNA polymerase 3
• forms polymerase active center together with 2nd largest subunit
• a bridging helix emanates from POLR3A & crosses the cleft near the catalytic site & is thought to promote translocation of RNA polymerase 3 by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (putative)

Structure

belongs to the RNA polymerase beta' chain family

Compartment

nucleus

More general terms

• RNA polymerase L'

Component of

• RNA polymerase 3

Database

• UniProt: http://www.uniprot.org/uniprot/O14802.html