hemoglobin gamma-1 chain

Function

• see hemoglobin gamma
• component of hemoglobin F together with alpha globin
• acetylation of Gly-2 converts Hb F to the minor Hb F1

Expression

• erythrocytes
• expressed until 4-5 weeks after birth

Pathology

• some gamma variants can cause severe jaundice & cyanosis in premature & new born babies
• with deletions affecting one or more of the alpha chains, the excess gamma chains form homotetramers that exhibit neither Bohr effect nor heme-heme cooperativity (hemoglobin Bart's)

More general terms

• hemoglobin gamma chain

Database

• OMIM: https://mirror.omim.org/entry/142200
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3047
• UniProt: http://www.uniprot.org/uniprot/P69891.html