dynein heavy chain 6, axonemal (DNAH6, DNAHC6, HL2, KIAA1697)

Function

• dynein heavy chain
• force generating protein of respiratory cilia
• produces force towards the minus ends of microtubules
• dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (putative) The dynein complex consists of at least two heavy chains & a number of intermediate & light chains (putative)

Structure

• dynein complex consists of at least two heavy chains & a number of intermediate & light chains (putative)
• dynein heavy chains probably consist of an N-terminal stem (which binds cargo & interacts with other dynein components), & the head or motor domain
• the motor contains six tandemly- linked AAA domains in the head, which form a ring
• a stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 & AAA 5 & terminates in a microtubule-binding site
• seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain
• there are four well-conserved & two non-conserved ATPase sites, one per AAA domain
• probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (putative)
• belongs to the dynein heavy chain family

Alternative splicing

named isoforms=4

Expression

detected in brain, testis & trachea

More general terms

• dynein heavy chain

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2849
• OMIM: https://mirror.omim.org/entry/603336
• UniProt: http://www.uniprot.org/uniprot/Q9C0G6.html