dynein heavy chain 6, axonemal (DNAH6, DNAHC6, HL2, KIAA1697)

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Function

Structure

  • dynein complex consists of at least two heavy chains & a number of intermediate & light chains (putative)
  • dynein heavy chains probably consist of an N-terminal stem (which binds cargo & interacts with other dynein components), & the head or motor domain
  • the motor contains six tandemly- linked AAA domains in the head, which form a ring
  • a stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 & AAA 5 & terminates in a microtubule-binding site
  • seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain
  • there are four well-conserved & two non-conserved ATPase sites, one per AAA domain
  • probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (putative)
  • belongs to the dynein heavy chain family

Alternative splicing

named isoforms=4

Expression

detected in brain, testis & trachea

More general terms

References

Database