acyl-protein thioesterase 1; hAPT1; lysophospholipase 1; lysoPLA I (LYPLA1, APT1, LPL1)

Function

• hydrolyzes fatty acids from S-acylated Cys
  • trimeric G alpha proteins
  • HRAS
• low lysophospholipase activity

palmitoyl-protein + H2O <--> palmitate + protein

Inhibition:

• inhibited by palmostatin-B

Structure

• homodimer
• belongs to the AB hydrolase 2 family

Compartment

cytoplasm

Alternative splicing

named isoforms=2

More general terms

• thiol esterase or thioesterase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10434
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10434
• OMIM: https://mirror.omim.org/entry/605599
• UniProt: http://www.uniprot.org/uniprot/O75608.html