acyl peptide hydrolase; acylamino acid-releasing enzyme; DNF15S2 protein; oxidized protein hydrolase; OPH (APH, APEH, D3F15S2, D3S48E, DNF15S2)

Function

• catalyzes hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid & a peptide with a free N-terminus
• preferentially cleaves off Ac-Ala, Ac-Met & Ac-Ser
• cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide

Structure

• homotetramer
• belongs to the peptidase S9C family
• mass spec: mass=81269.9; mass_error=8.7 method=electrospray; Range=1-732;

Compartment

cytoplasm

More general terms

• prolyl oligopeptidase family

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:327
• UniProt: http://www.uniprot.org/uniprot/P13798.html
• OMIM: https://mirror.omim.org/entry/102645