hepsin; serine protease hepsin; transmembrane protease serine 1 (HPN, TMPRSS1)

Function

• role in cell growth & maintenance of cell morphology
• cleavage after basic amino-acid residues, with Arg strongly preferred to Lys

Structure

• belongs to the peptidase S1 family
• contains 1 peptidase S1 domain
• contains 1 SRCR domain

Compartment

membrane

Expression

• present in most tissues
• highest level in liver

Pathology

• expressed in high levels in malignant prostate tissue, but absent in metastatic tissue

More general terms

• serine protease trypsin family

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3249
• OMIM: https://mirror.omim.org/entry/142440
• UniProt: http://www.uniprot.org/uniprot/P05981.html