ubiquitin carboxyl-terminal hydrolase BAP1; BRCA1-associated protein 1; cerebral protein 6 (BAP1, KIAA0272, hucep-6)

Function

• deubiquitinating enzyme
• thiol-dependent hydrolysis of ester,thiolester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
• may be involved in BRCA1 signal transduction pathway.
• interacts with the RING finger domain of BRCA1

Compartment

nucleus

Expression

expressed testis, placenta, ovary, breast

Pathology

• defects in BAP1 are found in non-small cell lung cancer cell lines
• tumor-associated antigen found in some childhood medulloblastomas

More general terms

• ubiquitin C-terminal hydrolase

Database

• OMIM: https://mirror.omim.org/entry/603089
• UniProt: http://www.uniprot.org/uniprot/Q92560.html