ubiquitin carboxyl-terminal hydrolase 43; deubiquitinating enzyme 43; ubiquitin thiolesterase 43; ubiquitin-specific-processing protease 43 (USP43)

Function

• may recognize & hydrolyze the peptide bond at the C-terminal Gly of ubiquitin
• role in processing of poly-ubiquitin precursors as well as that of ubiquinated proteins
• thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin

Structure

belongs to the peptidase C19 family

Alternative splicing

named isoforms=3

Expression

• expressed in brain, aorta & lung at low levels

More general terms

• ubiquitin C-terminal hydrolase
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=124739
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:124739
• UniProt: http://www.uniprot.org/uniprot/Q70EL4.html