ubiquitin carboxyl-terminal hydrolase 26; deubiquitinating enzyme 26; ubiquitin thiolesterase 26; ubiquitin-specific-processing protease 26 (USP26)

Function

• role in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (putative)
• deubiquinates the androgen receptor & regulates the androgen receptor signaling pathway
• thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin
• interacts with AR

Structure

belongs to the peptidase C19 family

Compartment

nucleus

More general terms

• ubiquitin C-terminal hydrolase
• nuclear protein

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83844
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:83844
• OMIM: https://mirror.omim.org/entry/300309
• UniProt: http://www.uniprot.org/uniprot/Q9BXU7.html