Ubl carboxyl-terminal hydrolase 18; 43 kD ISG15-specific protease; hUBP43; ISG15-specific-processing protease; Ubl thiolesterase 18 (USP18 ISG43)

Function

• can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds
• necessary to maintain cellular balance of ISG15-conjugated proteins in both healthy & stressed organisms
• thiol-dependent hydrolysis of ester, thioester, amide, peptide & isopeptide bonds formed by the C-terminal Gly of ubiquitin

Structure

belongs to the peptidase C19 family

More general terms

• ubiquitin C-terminal hydrolase

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11274
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11274
• OMIM: https://mirror.omim.org/entry/607057
• UniProt: http://www.uniprot.org/uniprot/Q9UMW8.html