macrophage receptor MARCO; macrophage receptor with collagenous structure; scavenger receptor class A member 2 (MARCO, SCARA2)

Function

• pattern recognition receptor
• binds Gram-positive bacteria & Gram-negative bacteria

Structure

• homotrimer
• homotrimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands (putative)
• contains 1 collagen-like domain
• contains 1 SRCR domain

Compartment

• membrane ; single-pass type 2 membrane protein

Alternative splicing

named isoforms=2

More general terms

• scavenger receptor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8685
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8685
• OMIM: https://mirror.omim.org/entry/604870
• UniProt: http://www.uniprot.org/uniprot/Q9UEW3.html