liprin-beta-1; protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1; PTPRF-interacting protein-binding protein 1; hSGT2 (PPFIBP1, KIAA1230)

Function

• may regulate disassembly of focal adhesions
• does not bind receptor-like tyrosine phosphatases type 2A
• forms homodimers & heterodimers. interacts with S100A4 (Ca+2-dependent)

Structure

• the N-terminal coiled coil regions mediate homodimerization preferentially & heterodimerization type beta/beta
• the C-terminal, non-coiled coil regions mediate heterodimerization type beta/alpha & interaction with S100A4
• belongs to the liprin family, liprin-beta subfamily
• contains 3 SAM (sterile alpha motif) domains

Alternative splicing

named isoforms=5

Expression

• widely expressed
• absent in liver

More general terms

• liprin-beta

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8496
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8496
• OMIM: https://mirror.omim.org/entry/603141
• UniProt: http://www.uniprot.org/uniprot/Q86W92.html