hydroymethylglutaryl (HMG) CoA synthase-2 (mitochondrial, HMGCS2)

Function

• condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA
• mevalonate biosynthesis; R-mevalonate from acetyl-CoA, step 2/3

context: sterol (i.e. cholesterol) & isoprenoid biosynthesis

acetyl-CoA + H2O + acetoacetyl-CoA
        <-->
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA

Structure

belongs to the HMG-CoA synthase family

Compartment

cytoplasm

More general terms

• hydroxymethylglutaryl [HMG] CoA synthase

Additional terms

• cholesterol biosynthesis

Database

• OMIM: https://mirror.omim.org/entry/600234
• UniProt: http://www.uniprot.org/uniprot/P54868.html