aldehyde dehydrogenase 5 family, member A1; succinate semialdehyde dehydrogenase; NAD+ dependent succinic semialdehyde dehydrogenase (ALDH5A1, SSADH)

Function

• 4-aminobutyrate (GABA) degradation

succinate semialdehyde + NAD+ + H2O <--> succinate + NADH

Structure

• homotetramer
• belongs to the aldehyde dehydrogenase family

Compartment

mitochondria

Expression

• expressioned in brain, pancreas, heart, liver, skeletal muscle & kidney
• lower in placenta

Pathology

• defects associated with 4-hydroxybutyricaciduria - inborn error in metabolism of GABA

Laboratory

• succinate semialdehyde dehydrogenase in leukocytes

More general terms

• aldehyde dehydrogenase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7915
• OMIM: https://mirror.omim.org/entry/271980
• UniProt: http://www.uniprot.org/uniprot/P51649.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7915