aldehyde dehydrogenase 1 family, member A3 (aldehyde dehydrogenase 6, acetaldehyde dehydrogenase 6, RALDH-3, ALDH1A3, ALDH6)

Function

• recognizes as substrates free retinaldehyde & retinaldehyde bound to cellular retinol-binding protein
• seems to be the key enzyme in the formation of retinoic acid gradient along the dorso-ventral axis during the early eye development & also in the development of the olfactory system (putative)
• retinoic acid biosynthesis

an aldehyde + NAD+/NADP+ + H2O <--> an acid + NADH/NADPH

Structure

belongs to the aldehyde dehydrogenase family

Compartment

cytoplasm (putative)

Expression

• expressed at low levels in many tissues & at higher levels in salivary gland, stomach, & kidney

More general terms

• aldehyde dehydrogenase

Database

• OMIM: https://mirror.omim.org/entry/600463
• UniProt: http://www.uniprot.org/uniprot/P47895.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:220;
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=220