tyrosyl-tRNA synthetase (tyrosyl-tRNA ligase, TyrRS, YARS, TYRRS , YTS)

Function

-..........-

ATP + L-tyrosine + tRNA(Tyr)
            <-->
AMP +  diphosphate + L-tyrosyl-tRNA(Tyr)

Structure

• homodimer
• belongs to aminoacyl-tRNA synthetase-1 family
• contains 1 tRNA-binding domain

Compartment

cytoplasm

Pathology

• defects in YARS associated with Charcot-Marie-Tooth disease dominant intermediate C (CMTDIC)

More general terms

• amino acyl tRNA synthetase-1

Additional terms

• Charcot-Marie-Tooth disease dominant intermediate C (CMTDIC)

Database

• OMIM: https://mirror.omim.org/entry/603623
• OMIM: https://mirror.omim.org/entry/608323
• UniProt: http://www.uniprot.org/uniprot/P54577.html