arginyl tRNA synthetase (arginine tRNA ligase, ArgRS, RARS)

Function

• component of multisynthetase complex

ATP + L-arginine + tRNA(Arg)
           <-->
AMP + diphosphate + L-arginyl-tRNA(Arg)

Structure

• monomer
• N-terminus (AA 1-72) has 2 regions with predicted alpha-helix that might be involved in multisynthetase complex assembly
• belongs to taminoacyl-tRNA synthetase-1 family

Compartment

cytoplasm

Alternative initiation

named isoforms=2

More general terms

• amino acyl tRNA synthetase-1

Component of

• multisynthetase complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5917
• OMIM: https://mirror.omim.org/entry/107820
• UniProt: http://www.uniprot.org/uniprot/P54136.html