bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing); includes: ATP-dependent dihydroxyacetone kinase; DHA kinase; glycerone kinase; FAD-AMP lyase (cyclizing); FAD-AMP lyase (cyclic FMN forming); FMN cyclase (DAK)

Function

• catalyzes both the phosphorylation of dihydroxyacetone & splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate
• each activity is inhibited by the substrate(s) of the other

ATP + glycerone = ADP + glycerone phosphate

FAD = AMP + riboflavin cyclic-4',5'-phosphate

Cofactor:

• Mg+2 (putative)
• Mn+2 or cobalt; for FAD-AMP lyase activity

Structure

• homodimer (putative)
• belongs to the dihydroxyacetone kinase (DAK) family
• contains 1 DhaK domain
• contains 1 DhaL domain

More general terms

• kinase or ATP-phosphotransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26007
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26007
• UniProt: http://www.uniprot.org/uniprot/Q3LXA3.html