uridine-cytidine kinase-like 1 (UCKL1, URKL1, F538)

Function

• may contribute to UTP accumulation needed for blast transformation & proliferation
• pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3
• pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1
• ubiquitinated by RNF19B; which induces proteasomal degradation
• interacts with RNF19B & EBV EBNA3

ATP + uridine = ADP + UMP

ATP + cytidine = ADP + CMP

Structure

belongs to the uridine kinase family

Compartment

• cytoplasm, nucleus
• EBNA3 induces isoform 1 translocation to the nucleus

Alternative splicing

named isoforms=3

Expression

ubiquitous

More general terms

• kinase or ATP-phosphotransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54963
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54963
• OMIM: https://mirror.omim.org/entry/610866
• UniProt: http://www.uniprot.org/uniprot/Q9NWZ5.html