selenide, water dikinase 1; selenium donor protein 1; selenophosphate synthase 1 (SEPHS1, SELD SPS, SPS1)

Function

• synthesizes selenophosphate from selenide & ATP
• activated by phosphate & by K+

ATP + selenide + H2O = AMP + selenophosphate + phosphate

Structure

• homodimer
• belongs to the selenophosphate synthase 1 family class II subfamily
• the conserved active site Cys (or selenocysteine) residue in position 29 is replaced by a Thr; however, as function in selenoprotein synthesis is proven, it is possible Cys-31 is the active site

More general terms

• kinase or ATP-phosphotransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22929
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22929
• OMIM: https://mirror.omim.org/entry/600902
• UniProt: http://www.uniprot.org/uniprot/P49903.html