5-phosphomevalonate kinase (PMVK)

Function

• role in cholesterol biosynthesis
• role in isoprenoid biosynthesis; isopentenyl-PP biosynthesis via mevalonate pathway; isopentenyl-PP from R-mevalonate: step 2/3

ATP + (R)-5-phosphomevalonate
           <-->
ADP + (R)-mevalonate-5-pyrophosphate

Structure

monomer (putative)

Compartment

peroxisome

Expression

• expressed in heart, liver, skeletal muscle, kidney, & pancreas > brain, placenta, & lung
• induced by sterol

Pathology

• point mutations associated with linear porokeratosis

More general terms

• kinase or ATP-phosphotransferase

Additional terms

• cholesterol biosynthesis

Database

• UniProt: http://www.uniprot.org/uniprot/Q15126.html