adenosine kinase (adenosine 5'-phosphotransferase, ADK)

Function

• ATP dependent phosphorylation of adenosine & other related nucleoside analogs to monophosphate derivatives
• potential regulator of concentrations of extracellular adenosine & intracellular adenine nucleotides
• urine metabolism; AMP biosynthesis via salvage pathway
• AMP from adenosine: step 1/1

ATP + adenosine <--> ADP + AMP

Cofactor: binds 3 Mg+2 per subunit

Structure

• monomer
• belongs to the carbohydrate kinase pfkB family

Alternative splicing

named isoforms=2

Expression

• widely expressed
• highest level in placenta, liver, muscle & kidney

More general terms

• kinase or ATP-phosphotransferase

Database

• OMIM: https://mirror.omim.org/entry/102750
• UniProt: http://www.uniprot.org/uniprot/P55263.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=132